Technology
Jillion's
Reinventing Drug Discovery
In-house synergies: Empowering Innovation with High-Power Screening (HPS) and DNA-Encoded Libraries
At Jillion Therapeutics, we harness the transformative power of High-Power Screening (HPS) combined with our own and proprietary DNA-Encoded Library (DEL) technologies. This potent synergy is the engine behind our relentless pursuit of novel therapeutics for complex neurological diseases.
High-Power Screening (HPS)
Jillion's team coined the term “HPS” in our review "High-power screening (HPS) empowered by DNA-encoded libraries" published in Trends in Pharmacological Sciences (2022 Jan; 43(1):4-15).
DEL enables the rapid, simultaneous screening of a vast number of real compounds in a single tube, within just a few days.
This large-scale screening significantly surpasses traditional HTS methods in both scope and efficiency.
By physically testing real compounds, synthesized in only 2 to 3 steps, DEL offers considerable advantages over in-silico screening approaches, delivering more reliable and actionable results.
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Synthetic organic chemistry: from DNA-Encoded Libraries (DELs) to off-DNA lead compounds
The cornerstone of our HPS system is the DNA-Encoded Library technology. We are designing and building our own focussed DEL libraries to reframe the way HPS is used.
Jillion’s deep expertise in organic chemistry, led by our Senior Chemist, ensures full control over the design and development of unique, focused DEL libraries, utilizing proprietary methods and internal know-how.
More importantly it enables the rapid in-house generation of drug-like compounds.
Hit & lead optimization through A.I.
DELs are vast collections of small molecules where each compound is tagged with a unique DNA sequence that acts as a barcode. This ingenious coupling allows us to perform selections against targets of interest in ways that were not possible before. Swift decoding identities binding molecules through DNA sequencing (NGS).
DEL compounds, are real, easy and quick to synthetize, making them ideal drug-like compounds and a solid foundation for A.I. optimization.
